Meta‐analysis of genome‐wide linkage scans of attention deficit hyperactivity disorder
Identifieur interne : 001130 ( Main/Exploration ); précédent : 001129; suivant : 001131Meta‐analysis of genome‐wide linkage scans of attention deficit hyperactivity disorder
Auteurs : Kaixin Zhou [Royaume-Uni] ; Astrid Dempfle [Allemagne] ; Mauricio Arcos-Burgos [États-Unis] ; Steven C. Bakker [Pays-Bas] ; Tobias Banaschewski [Allemagne] ; Joseph Biederman [États-Unis] ; Jan Buitelaar [Pays-Bas] ; F. Xavier Castellanos [États-Unis] ; Alysa Doyle [États-Unis] ; Richard P. Ebstein [Israël] ; Jenny Ekholm [États-Unis] ; Paola Forabosco [Royaume-Uni, Italie] ; Barbara Franke [Pays-Bas] ; Christine Freitag [Allemagne] ; Susann Friedel [Allemagne] ; Michael Gill [Irlande (pays)] ; Johannes Hebebrand [Allemagne] ; Anke Hinney [Allemagne] ; Christian Jacob [Allemagne] ; Klaus Peter Lesch [Allemagne] ; Sandra K. Loo [États-Unis] ; Francisco Lopera [Colombie] ; James T. Mccracken [États-Unis] ; James J. Mcgough [États-Unis] ; Jobst Meyer [Allemagne] ; Eric Mick [États-Unis] ; Ana Miranda [Espagne] ; Maximilian Muenke1 [États-Unis] ; Fernando Mulas [Espagne] ; Stanley F. Nelson [États-Unis] ; T. Trang Nguyen [Allemagne] ; Robert D. Oades [Allemagne] ; Matthew N. Ogdie [États-Unis] ; Juan David Palacio [Colombie] ; David Pineda [Colombie] ; Andreas Reif [Allemagne] ; Tobias J. Renner [Allemagne] ; Herbert Roeyers [Belgique] ; Marcel Romanos [Allemagne] ; Aribert Rothenberger [Allemagne] ; Helmut Sch Fer [Allemagne] ; Joseph Sergeant [Pays-Bas] ; Richard J. Sinke [Pays-Bas] ; Susan L. Smalley [États-Unis] ; Edmund Sonuga-Barke [Royaume-Uni, États-Unis] ; Hans-Christoph Steinhausen [Suisse] ; Emma Van Der Meulen [Pays-Bas] ; Susanne Walitza [Allemagne] ; Andreas Warnke [Allemagne] ; Cathryn M. Lewis [Royaume-Uni] ; Stephen V. Faraone [États-Unis] ; Philip Asherson [Royaume-Uni]Source :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics [ 1552-4841 ] ; 2008-12-05.
English descriptors
Abstract
Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome‐wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome‐wide significant linkage (PSR = 0.00034, POR = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes. © 2008 Wiley‐Liss, Inc.
Url:
- https://api.istex.fr/document/B0F83818028A4010A3FEE7AA60DBB739E3DAB998/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890047
DOI: 10.1002/ajmg.b.30878
Affiliations:
- Allemagne, Belgique, Colombie, Espagne, Irlande (pays), Israël, Italie, Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Angleterre, Bade-Wurtemberg, Californie, Canton de Zurich, District de Giessen, District de Karlsruhe, Floride, Grand Londres, Gueldre, Hesse (Land), Hollande-Septentrionale, Maryland, Massachusetts, Province de Flandre-Orientale, Rhénanie-Palatinat, Région flamande, Utrecht (province), État de New York
- Amsterdam, Gand, Londres, Mannheim, Marbourg, Nimègue, Trèves (Allemagne), Utrecht, Zurich
- Université de Gand, Université de Trèves, Université de Zurich
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Le document en format XML
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Xavier" last="Castellanos">F. Xavier Castellanos</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Child Study Center, New York University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Doyle, Alysa" sort="Doyle, Alysa" uniqKey="Doyle A" first="Alysa" last="Doyle">Alysa Doyle</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Ebstein, Richard P" sort="Ebstein, Richard P" uniqKey="Ebstein R" first="Richard P." last="Ebstein">Richard P. 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sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name><affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Psychiatry, Trinity Centre for Health Sciences, St. James's Hospital, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Hebebrand, Johannes" sort="Hebebrand, Johannes" uniqKey="Hebebrand J" first="Johannes" last="Hebebrand">Johannes Hebebrand</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Hinney, Anke" sort="Hinney, Anke" uniqKey="Hinney A" first="Anke" last="Hinney">Anke Hinney</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Child and Adolescent Psychiatry, University of Duisburg‐Essen, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Jacob, Christian" sort="Jacob, Christian" uniqKey="Jacob C" first="Christian" last="Jacob">Christian Jacob</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Lesch, Klaus Peter" sort="Lesch, Klaus Peter" uniqKey="Lesch K" first="Klaus Peter" last="Lesch">Klaus Peter Lesch</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Loo, Sandra K" sort="Loo, Sandra K" uniqKey="Loo S" first="Sandra K." last="Loo">Sandra K. Loo</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Lopera, Francisco" sort="Lopera, Francisco" uniqKey="Lopera F" first="Francisco" last="Lopera">Francisco Lopera</name><affiliation wicri:level="1"><country xml:lang="fr">Colombie</country><wicri:regionArea>Neurosciences Group, University of Antioquia, Medellín</wicri:regionArea><wicri:noRegion>Medellín</wicri:noRegion></affiliation></author><author><name sortKey="Mccracken, James T" sort="Mccracken, James T" uniqKey="Mccracken J" first="James T." last="Mccracken">James T. Mccracken</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Mcgough, James J" sort="Mcgough, James J" uniqKey="Mcgough J" first="James J." last="Mcgough">James J. Mcgough</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurobehavioral Genetics, University of Trier, Trier</wicri:regionArea><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Mick, Eric" sort="Mick, Eric" uniqKey="Mick E" first="Eric" last="Mick">Eric Mick</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Miranda, Ana" sort="Miranda, Ana" uniqKey="Miranda A" first="Ana" last="Miranda">Ana Miranda</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Developmental and Educational Psychology, University of Valencia, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Muenke1, Maximilian" sort="Muenke1, Maximilian" uniqKey="Muenke1 M" first="Maximilian" last="Muenke1">Maximilian Muenke1</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Mulas, Fernando" sort="Mulas, Fernando" uniqKey="Mulas F" first="Fernando" last="Mulas">Fernando Mulas</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neuropaediatric, La Fe University Hospital, Faculty of Medicine, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Nelson, Stanley F" sort="Nelson, Stanley F" uniqKey="Nelson S" first="Stanley F." last="Nelson">Stanley F. Nelson</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Human Genetics, UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Nguyen, T Trang" sort="Nguyen, T Trang" uniqKey="Nguyen T" first="T. Trang" last="Nguyen">T. Trang Nguyen</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry and Epidemiology, Philipps‐University Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Oades, Robert D" sort="Oades, Robert D" uniqKey="Oades R" first="Robert D." last="Oades">Robert D. Oades</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Clinic for Child and Adolescent Psychiatry, Essen</wicri:regionArea><wicri:noRegion>Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Ogdie, Matthew N" sort="Ogdie, Matthew N" uniqKey="Ogdie M" first="Matthew N." last="Ogdie">Matthew N. Ogdie</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>The Broad Institute, MIT, Cambridge</wicri:cityArea></affiliation></author><author><name sortKey="Palacio, Juan David" sort="Palacio, Juan David" uniqKey="Palacio J" first="Juan David" last="Palacio">Juan David Palacio</name><affiliation wicri:level="1"><country xml:lang="fr">Colombie</country><wicri:regionArea>Neurosciences Group, University of Antioquia, Medellín</wicri:regionArea><wicri:noRegion>Medellín</wicri:noRegion></affiliation></author><author><name sortKey="Pineda, David" sort="Pineda, David" uniqKey="Pineda D" first="David" last="Pineda">David Pineda</name><affiliation wicri:level="1"><country xml:lang="fr">Colombie</country><wicri:regionArea>Neurosciences Group, University of Antioquia, Medellín</wicri:regionArea><wicri:noRegion>Medellín</wicri:noRegion></affiliation></author><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>ADHD Clinical Research Program, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Renner, Tobias J" sort="Renner, Tobias J" uniqKey="Renner T" first="Tobias J." last="Renner">Tobias J. Renner</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Roeyers, Herbert" sort="Roeyers, Herbert" uniqKey="Roeyers H" first="Herbert" last="Roeyers">Herbert Roeyers</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Ghent University, Dunantlaan, Ghent</wicri:regionArea><orgName type="university">Université de Gand</orgName><placeName><settlement type="city">Gand</settlement><region>Région flamande</region><region type="district" nuts="2">Province de Flandre-Orientale</region></placeName></affiliation></author><author><name sortKey="Romanos, Marcel" sort="Romanos, Marcel" uniqKey="Romanos M" first="Marcel" last="Romanos">Marcel Romanos</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Rothenberger, Aribert" sort="Rothenberger, Aribert" uniqKey="Rothenberger A" first="Aribert" last="Rothenberger">Aribert Rothenberger</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Child and Adolescent Psychiatry, University of Gottingen, Gottingen</wicri:regionArea><wicri:noRegion>Gottingen</wicri:noRegion><wicri:noRegion>Gottingen</wicri:noRegion></affiliation></author><author><name sortKey="Sch Fer, Helmut" sort="Sch Fer, Helmut" uniqKey="Sch Fer H" first="Helmut" last="Sch Fer">Helmut Sch Fer</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry and Epidemiology, Philipps‐University Marburg, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Sergeant, Joseph" sort="Sergeant, Joseph" uniqKey="Sergeant J" first="Joseph" last="Sergeant">Joseph Sergeant</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Vrije Universiteit, De Boelelaan, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Sinke, Richard J" sort="Sinke, Richard J" uniqKey="Sinke R" first="Richard J." last="Sinke">Richard J. Sinke</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Genetics, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Smalley, Susan L" sort="Smalley, Susan L" uniqKey="Smalley S" first="Susan L." last="Smalley">Susan L. Smalley</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center for Neurobehavioral Genetics, Semel Institute for Neuroscience & Human Behavior, UCLA, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Sonuga Arke, Edmund" sort="Sonuga Arke, Edmund" uniqKey="Sonuga Arke E" first="Edmund" last="Sonuga-Barke">Edmund Sonuga-Barke</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Child Study Center, New York University, New York</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Psychology, Institute for Disorder on Impulse and Attention, University of Southampton, Highfield, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Steinhausen, Hans Hristoph" sort="Steinhausen, Hans Hristoph" uniqKey="Steinhausen H" first="Hans-Christoph" last="Steinhausen">Hans-Christoph Steinhausen</name><affiliation wicri:level="4"><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Child and Adolescent Psychiatry, University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Van Der Meulen, Emma" sort="Van Der Meulen, Emma" uniqKey="Van Der Meulen E" first="Emma" last="Van Der Meulen">Emma Van Der Meulen</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Walitza, Susanne" sort="Walitza, Susanne" uniqKey="Walitza S" first="Susanne" last="Walitza">Susanne Walitza</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Warnke, Andreas" sort="Warnke, Andreas" uniqKey="Warnke A" first="Andreas" last="Warnke">Andreas Warnke</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg</wicri:regionArea><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Lewis, Cathryn M" sort="Lewis, Cathryn M" uniqKey="Lewis C" first="Cathryn M" last="Lewis">Cathryn M. Lewis</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medical and Molecular Genetics, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Faraone, Stephen V" sort="Faraone, Stephen V" uniqKey="Faraone S" first="Stephen V." last="Faraone">Stephen V. Faraone</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Psychiatry, SUNY Upstate Medical University, Syracuse</wicri:cityArea></affiliation></author><author><name sortKey="Asherson, Philip" sort="Asherson, Philip" uniqKey="Asherson P" first="Philip" last="Asherson">Philip Asherson</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London SE5 8AF</wicri:regionArea><wicri:noRegion>King's College London SE5 8AF</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">American Journal of Medical Genetics Part B: Neuropsychiatric Genetics</title><title level="j" type="abbrev">Am. J. Med. Genet.</title><idno type="ISSN">1552-4841</idno><idno type="eISSN">1552-485X</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-12-05">2008-12-05</date><biblScope unit="volume">147B</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1392">1392</biblScope><biblScope unit="page" to="1398">1398</biblScope></imprint><idno type="ISSN">1552-4841</idno></series><idno type="istex">B0F83818028A4010A3FEE7AA60DBB739E3DAB998</idno><idno type="DOI">10.1002/ajmg.b.30878</idno><idno type="ArticleID">AJMG30878</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1552-4841</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ADHD</term><term>GSMA</term><term>linkage</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome‐wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome‐wide significant linkage (PSR = 0.00034, POR = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes. © 2008 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Belgique</li><li>Colombie</li><li>Espagne</li><li>Irlande (pays)</li><li>Israël</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Californie</li><li>Canton de Zurich</li><li>District de Giessen</li><li>District de Karlsruhe</li><li>Floride</li><li>Grand Londres</li><li>Gueldre</li><li>Hesse (Land)</li><li>Hollande-Septentrionale</li><li>Maryland</li><li>Massachusetts</li><li>Province de Flandre-Orientale</li><li>Rhénanie-Palatinat</li><li>Région flamande</li><li>Utrecht (province)</li><li>État de New York</li></region><settlement><li>Amsterdam</li><li>Gand</li><li>Londres</li><li>Mannheim</li><li>Marbourg</li><li>Nimègue</li><li>Trèves (Allemagne)</li><li>Utrecht</li><li>Zurich</li></settlement><orgName><li>Université de Gand</li><li>Université de Trèves</li><li>Université de Zurich</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Zhou, Kaixin" sort="Zhou, Kaixin" uniqKey="Zhou K" first="Kaixin" last="Zhou">Kaixin Zhou</name></region><name sortKey="Asherson, Philip" sort="Asherson, Philip" uniqKey="Asherson P" first="Philip" last="Asherson">Philip Asherson</name><name sortKey="Asherson, Philip" sort="Asherson, Philip" uniqKey="Asherson P" first="Philip" last="Asherson">Philip Asherson</name><name sortKey="Forabosco, Paola" sort="Forabosco, Paola" uniqKey="Forabosco P" first="Paola" last="Forabosco">Paola Forabosco</name><name sortKey="Lewis, Cathryn M" sort="Lewis, Cathryn M" uniqKey="Lewis C" first="Cathryn M" last="Lewis">Cathryn M. Lewis</name><name sortKey="Lewis, Cathryn M" sort="Lewis, Cathryn M" uniqKey="Lewis C" first="Cathryn M" last="Lewis">Cathryn M. Lewis</name><name sortKey="Sonuga Arke, Edmund" sort="Sonuga Arke, Edmund" uniqKey="Sonuga Arke E" first="Edmund" last="Sonuga-Barke">Edmund Sonuga-Barke</name><name sortKey="Sonuga Arke, Edmund" sort="Sonuga Arke, Edmund" uniqKey="Sonuga Arke E" first="Edmund" last="Sonuga-Barke">Edmund Sonuga-Barke</name></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Dempfle, Astrid" sort="Dempfle, Astrid" uniqKey="Dempfle A" first="Astrid" last="Dempfle">Astrid Dempfle</name></region><name sortKey="Banaschewski, Tobias" sort="Banaschewski, Tobias" uniqKey="Banaschewski T" first="Tobias" last="Banaschewski">Tobias Banaschewski</name><name sortKey="Freitag, Christine" sort="Freitag, Christine" uniqKey="Freitag C" first="Christine" last="Freitag">Christine Freitag</name><name sortKey="Friedel, Susann" sort="Friedel, Susann" uniqKey="Friedel S" first="Susann" last="Friedel">Susann Friedel</name><name sortKey="Hebebrand, Johannes" sort="Hebebrand, Johannes" uniqKey="Hebebrand J" first="Johannes" last="Hebebrand">Johannes Hebebrand</name><name sortKey="Hinney, Anke" sort="Hinney, Anke" uniqKey="Hinney A" first="Anke" last="Hinney">Anke Hinney</name><name sortKey="Jacob, Christian" sort="Jacob, Christian" uniqKey="Jacob C" first="Christian" last="Jacob">Christian Jacob</name><name sortKey="Lesch, Klaus Peter" sort="Lesch, Klaus Peter" uniqKey="Lesch K" first="Klaus Peter" last="Lesch">Klaus Peter Lesch</name><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><name sortKey="Nguyen, T Trang" sort="Nguyen, T Trang" uniqKey="Nguyen T" first="T. Trang" last="Nguyen">T. Trang Nguyen</name><name sortKey="Oades, Robert D" sort="Oades, Robert D" uniqKey="Oades R" first="Robert D." last="Oades">Robert D. Oades</name><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><name sortKey="Renner, Tobias J" sort="Renner, Tobias J" uniqKey="Renner T" first="Tobias J." last="Renner">Tobias J. Renner</name><name sortKey="Romanos, Marcel" sort="Romanos, Marcel" uniqKey="Romanos M" first="Marcel" last="Romanos">Marcel Romanos</name><name sortKey="Rothenberger, Aribert" sort="Rothenberger, Aribert" uniqKey="Rothenberger A" first="Aribert" last="Rothenberger">Aribert Rothenberger</name><name sortKey="Sch Fer, Helmut" sort="Sch Fer, Helmut" uniqKey="Sch Fer H" first="Helmut" last="Sch Fer">Helmut Sch Fer</name><name sortKey="Walitza, Susanne" sort="Walitza, Susanne" uniqKey="Walitza S" first="Susanne" last="Walitza">Susanne Walitza</name><name sortKey="Warnke, Andreas" sort="Warnke, Andreas" uniqKey="Warnke A" first="Andreas" last="Warnke">Andreas Warnke</name></country><country name="États-Unis"><region name="Floride"><name sortKey="Arcos Urgos, Mauricio" sort="Arcos Urgos, Mauricio" uniqKey="Arcos Urgos M" first="Mauricio" last="Arcos-Burgos">Mauricio Arcos-Burgos</name></region><name sortKey="Arcos Urgos, Mauricio" sort="Arcos Urgos, Mauricio" uniqKey="Arcos Urgos M" first="Mauricio" last="Arcos-Burgos">Mauricio Arcos-Burgos</name><name sortKey="Biederman, Joseph" sort="Biederman, Joseph" uniqKey="Biederman J" first="Joseph" last="Biederman">Joseph Biederman</name><name sortKey="Castellanos, F Xavier" sort="Castellanos, F Xavier" uniqKey="Castellanos F" first="F. Xavier" last="Castellanos">F. Xavier Castellanos</name><name sortKey="Doyle, Alysa" sort="Doyle, Alysa" uniqKey="Doyle A" first="Alysa" last="Doyle">Alysa Doyle</name><name sortKey="Ekholm, Jenny" sort="Ekholm, Jenny" uniqKey="Ekholm J" first="Jenny" last="Ekholm">Jenny Ekholm</name><name sortKey="Faraone, Stephen V" sort="Faraone, Stephen V" uniqKey="Faraone S" first="Stephen V." last="Faraone">Stephen V. Faraone</name><name sortKey="Faraone, Stephen V" sort="Faraone, Stephen V" uniqKey="Faraone S" first="Stephen V." last="Faraone">Stephen V. Faraone</name><name sortKey="Loo, Sandra K" sort="Loo, Sandra K" uniqKey="Loo S" first="Sandra K." last="Loo">Sandra K. Loo</name><name sortKey="Mccracken, James T" sort="Mccracken, James T" uniqKey="Mccracken J" first="James T." last="Mccracken">James T. Mccracken</name><name sortKey="Mcgough, James J" sort="Mcgough, James J" uniqKey="Mcgough J" first="James J." last="Mcgough">James J. Mcgough</name><name sortKey="Mick, Eric" sort="Mick, Eric" uniqKey="Mick E" first="Eric" last="Mick">Eric Mick</name><name sortKey="Muenke1, Maximilian" sort="Muenke1, Maximilian" uniqKey="Muenke1 M" first="Maximilian" last="Muenke1">Maximilian Muenke1</name><name sortKey="Nelson, Stanley F" sort="Nelson, Stanley F" uniqKey="Nelson S" first="Stanley F." last="Nelson">Stanley F. Nelson</name><name sortKey="Ogdie, Matthew N" sort="Ogdie, Matthew N" uniqKey="Ogdie M" first="Matthew N." last="Ogdie">Matthew N. Ogdie</name><name sortKey="Smalley, Susan L" sort="Smalley, Susan L" uniqKey="Smalley S" first="Susan L." last="Smalley">Susan L. Smalley</name><name sortKey="Smalley, Susan L" sort="Smalley, Susan L" uniqKey="Smalley S" first="Susan L." last="Smalley">Susan L. Smalley</name><name sortKey="Sonuga Arke, Edmund" sort="Sonuga Arke, Edmund" uniqKey="Sonuga Arke E" first="Edmund" last="Sonuga-Barke">Edmund Sonuga-Barke</name></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Bakker, Steven C" sort="Bakker, Steven C" uniqKey="Bakker S" first="Steven C." last="Bakker">Steven C. Bakker</name></region><name sortKey="Buitelaar, Jan" sort="Buitelaar, Jan" uniqKey="Buitelaar J" first="Jan" last="Buitelaar">Jan Buitelaar</name><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><name sortKey="Sergeant, Joseph" sort="Sergeant, Joseph" uniqKey="Sergeant J" first="Joseph" last="Sergeant">Joseph Sergeant</name><name sortKey="Sinke, Richard J" sort="Sinke, Richard J" uniqKey="Sinke R" first="Richard J." last="Sinke">Richard J. Sinke</name><name sortKey="Van Der Meulen, Emma" sort="Van Der Meulen, Emma" uniqKey="Van Der Meulen E" first="Emma" last="Van Der Meulen">Emma Van Der Meulen</name></country><country name="Israël"><noRegion><name sortKey="Ebstein, Richard P" sort="Ebstein, Richard P" uniqKey="Ebstein R" first="Richard P." last="Ebstein">Richard P. Ebstein</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Forabosco, Paola" sort="Forabosco, Paola" uniqKey="Forabosco P" first="Paola" last="Forabosco">Paola Forabosco</name></noRegion></country><country name="Irlande (pays)"><noRegion><name sortKey="Gill, Michael" sort="Gill, Michael" uniqKey="Gill M" first="Michael" last="Gill">Michael Gill</name></noRegion></country><country name="Colombie"><noRegion><name sortKey="Lopera, Francisco" sort="Lopera, Francisco" uniqKey="Lopera F" first="Francisco" last="Lopera">Francisco Lopera</name></noRegion><name sortKey="Palacio, Juan David" sort="Palacio, Juan David" uniqKey="Palacio J" first="Juan David" last="Palacio">Juan David Palacio</name><name sortKey="Pineda, David" sort="Pineda, David" uniqKey="Pineda D" first="David" last="Pineda">David Pineda</name></country><country name="Espagne"><noRegion><name sortKey="Miranda, Ana" sort="Miranda, Ana" uniqKey="Miranda A" first="Ana" last="Miranda">Ana Miranda</name></noRegion><name sortKey="Mulas, Fernando" sort="Mulas, Fernando" uniqKey="Mulas F" first="Fernando" last="Mulas">Fernando Mulas</name></country><country name="Belgique"><region name="Région flamande"><name sortKey="Roeyers, Herbert" sort="Roeyers, Herbert" uniqKey="Roeyers H" first="Herbert" last="Roeyers">Herbert Roeyers</name></region></country><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Steinhausen, Hans Hristoph" sort="Steinhausen, Hans Hristoph" uniqKey="Steinhausen H" first="Hans-Christoph" last="Steinhausen">Hans-Christoph Steinhausen</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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